NUTR 3330 Lecture Notes - Lecture 4: Pyridoxal Phosphate, Glycogen Phosphorylase, Pyridoxal
Document Summary
Vitamin b6 coenzyme form: pyridoxal phosphate (plp) - middle structure, riboflavin (fmn) needed to convert pyridoxine to plp, > 100 plp-dependent enzymes, involved heavily in amino acid metabolism, see oh structures. Vitamin b6 metabolic role: amino acid metabolism, primary role for vitamin b6, transamination, r-group interconversion (serine/glycine, decarboxylations, many aspects of intermediary metabolism; particularly gng, recall tryptophan metabolism, synthesis of what vitamin, niacin, kynurnine pathway. Assessing vitamin b6 status: load tests, load with substrate and see if it gets metabolism by the enzyme. Vitamin b6: deficiency: nervous system , irritability, depression, confusion, sleeplessness, 1950"s seizures observed in infants due to error in manufacturing of infant formula, vitamin b6 was destroyed so infant formula did not contain b6. B6 to achieve form: abnormal eeg patterns, dermatitis, cheilosis, stomatitis. Vitamin b12: largest and most complex structure of the b vitamins, cobalt central part of structure, also called cobalamin.
