NUTR 3330 Lecture Notes - Acetyl Group, Thiamine, Coenzyme A
7 Dec 2012
School
Department
Course
Professor
Document Summary
Present in foods in various bound forms intestinal enzymes cleave free pantothenic acid for absorption. Part of 2 major coenzymes: coenzyme a (coa, acyl carrier protein (acp) Coenzyme a - coash synthesized from cysteine, pantothenic acid & atp. Acetyl transfer reactions (2 carbon): connect to sh groups. Acetyl coa = central to nutrient metabolism. Many anabolic and catabolic fates: tca cycle, fa oxidation, acetylation reaction. Coa transferring acetyl groups examples: oxidative decarboxylation. Tca cycle needs vitamins thiamine (b1), riboflavin (b2), thiamine (b3), biotin: fatty acid oxidation. Beta-oxidation - fa degraded to acetyl coa fat metabolism acetyl coa ketone bodies: ketone body formation. Used as fuel when glucose is limiting: other carboxylic reactions. Many acyl coa intermediates: synthetic reactions cholesterol synthesis, hmg coa reductase rate limiting enzyme. Part of enzyme complex fatty acid synthase contains reactive sh group (cysteine: acp like coa, acyl groups added together to form palmitate, further elongation can occur.
