NUTR 3210 Lecture 8: MicronutrinOxiDef

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Nadh and fadh2 are principal carriers of electrons. Pass onto the o2 in the etc, produce water. Creation of atp from a number of reactions. Glycolysis, lactic acid production, pyruvate dehydrogenation, tca, gluconeogenesis, beta-oxidation. The efficiency of electron uptake by the etc is not 100%, it is about 99% This is means 1% of electrons leaked out. The electron donor becomes oxidized, the acceptor becomes reduced and vice versa. They are important in processes such as t3 t4 production (iodine becomes free radical) One o2 react with 4 electrons to form 2 h2o molecules. With leaking electrons from the mitochondria and in an o2 rich environment . Oxygen can react with one electron to produce superoxide anion radical. Superoxide anion radical can be converted to hydrogen peroxide. This enzyme takes the electrons from cu and zn and transfer them to superoxide anion radical. Any mutations in sod will cause catastrophic outcome (e. g. lou gehrig"s)

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