BIOM 3090 Lecture Notes - Lecture 5: Circulatory System, Ammonia, Aspirin
31 May 2016
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Document Summary
When we administer a drug, we usually administer it through a route that is more convenient, and it makes it to their site of action the drug needs to permeate through different barriers. Usually need a liberation phase where the active component of the drug is released from the rest of the product. There is an equilibrium between the drug moving in and out of the tissue/target sites. Exposed to the liver where the liver tries to metabolize and get rid of the drug. Adme (absorption, distribution, metabolism, and excretion) of a drug involves transport across cell membranes affected by several drug characteristics. Passive transport vs. carrier mediated= methods of drug transport across membranes. Most drugs are administered into one body compartment and move to their site of action. Drugs must permeate various barriers that separate compartments. Absorption, distribution, metabolism, and excretion of a drug involves the transport of the drug across cell membranes, which is affected by:
