BIOL 1090 Lecture Notes - Lecture 22: Lmna, Karyopherin, Progeria
21 Aug 2016
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Robert brown ==> introduced brownian motion of pollen (1827) Storage / replication / repair of genetic material. Separates nuclear content from cytoplasm (separates transcription and translation!) Mutations in the lamin gene (lmna) ==> hutchinson-gilson progeria syndrome! Wrinkles, hair loss, (older people features), early death :( Inner & outer membranes fuse @ pores (~120 nm diameter) Dna replication, repair, transcription, rna processing & exportation, ribosomes. Larger proteins have to cluster in a linear array to fit! Phenylalanine-glycine (fg) domains/repeats in npc help create mesh. Passive diffusion of small molecules (less than 9nm) Proteins of less than 40000 dalton size can freely diffuse! (ex: gfp, 27kd) Karyopherins = family of proteins --> transport receptors! Ras = rat sarcoma-protein (subfamily of small gtpases) Act as chemical messengers & triggers of molecular processes. B-importins carrying nls-containing protein interact with cytoplasmic filaments. Fg repeats interact with ran-gtp ==> dissociates complex! Export of proteins, rna molecules (rnps - ribonucleoproteins)
