KNES 437 Lecture Notes - Lecture 9: Calcitriol Receptor, Cholecalciferol, National Health And Nutrition Examination Survey
17 Feb 2020
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Knes 437 lecture 9 vitamin d and cancer. If offspring are born in the spring, they are more likely to be low in vitd because their mother must have had low sun exposure (winter: half-life is 2 weeks (inactive form, nhanes iii: 77% vitamin d insufficient. Cancer survival: survival significantly better for cancers diagnosed in summer & fall compared to spring & winter because of increased sun exposure in summer and fall months, seasonal effect strongest for breast & lung cancers. Light bars, women, n=3712: dark bars, men, n= 3723, subjects from uk, 45 yrs of age. Vitamin d: cholecalciferol = d3, not produced during winter months @ latitudes > 35 north or south, vitamin d supplements should be taken with food, endogenous pre-vitamin d3 is formed in the skin from uv b radiation exposure. Liver converts it to 25(oh)d = the inactive form, what we measure; 15 day. Half life: further hydroxylation steps in kidneys >>> biologically active form.
