CMMB 431 Lecture Notes - Lecture 17: Lipopolysaccharide, Signal Transduction, Translocon
25 Jun 2020
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Multiple strains, therefore can infect many bodily tissues. There is reservoir for it in north america. Symptom of plague: coagulation of vasculature in tissues leading to tissue death, so it turns black, hence the name. Y. pestis is hard to work with in the lab. Disease had natural cycles to it, so prevalence would increase, then wane, then come back. Pathogen has evolved several time and its though that the current form is similar to what might have caused the plague at in china at this time. Incidence map of all infections from usa. Majority of cases from dry regions in southern us, there is one outlier in chicago. It was a lab acquired infection, so someone was working with the pathogen. Yersinia psuedotuberculosis and enterocolitica acquired distinct virulence determinants that distinguish them from pestis: pestis. To make them virulent, change growth conditions that are host excessive factors.
