CMMB 403 Lecture Notes - Lecture 38: Lateral Plate Mesoderm, Splanchnic, Bone Morphogenetic Protein
8 Jan 2019
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Bilateral origin of the heart and heart looping. The heart is formed from two lateral patches of cells, on either side of the embryo in the splanchnic lateral plate mesoderm. This carcinogenic mesoderm is specified by wnt inhibitors and bmps from the underlying endoderm. The carcinogenic mesoderm forms a heart tube at the midline through embryonic folding and fusion of rudiments; atria are specified by retinoic acid from the posterior. The process of looping gives the heart its final three-dimensional form with atria at the anterior. Bilateral origin: heart comes from 2 populations of cells that are separated laterally (at opposite sides of embryo) Makes sense because have different signals to make different cells that are in the heart. High bmps are lateral in the early embryo. Bmp inhibitors made in the center of the embryo. Mesoderm forms the heart at the midline. 2 tubes that are lateral in the embryo that fuse together to form the heart.
