CMMB 403 Lecture Notes - Lecture 37: Intermediate Mesoderm, Pronephros, Bud Bud
7 Jan 2019
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How do we get this fabulously complex organ from the intermediate. On average, an adult kidney in humans has about 1-3 million nephrons. Development of the pronephros is the first step of a developmental cascade that ultimately produces the metanephric kidney. Pronephros is the first step of a developmental cascade and later degenerates. Generic mammalian kidney: pronephros develops quite anteriorly in the throat region. Metanephric kidney is the one we have in the back. Initially get pronephros, which starts a developmental cascade that allows metanephric kidney formation. Day 22: start making second kidney form. Get primitive tubules extending from nephrons that extend from mesonephros. Metanephric kidney later buds off from nephric bud. In amphibians and fish, this is their adult kidney form, they don"t make a metanephric kidney. Pronephroi begin developing early in the fourth week. Mesonephroi appear late in the fourth week. Mesonephric duct goes from anterior to posterior to form a tube.
