CMMB 403 Lecture Notes - Lecture 16: Maternal Effect, Chordin, Blastoderm
2 Dec 2018
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The maternal mrna coding for dorsal (and the translated protein) is distributed uniformly thorough the syncytial blastoderm. Dorsal protein is only translocated to the nuclei on the ventral side of the embryo. At dorsal side of embryo, dorsal protein is in the cytoplasm, complexed with cactus. At ventral side of the embryo, dorsal protein is in the nuclei because cactus has been degraded. Dorsal is only located in the dorsal side of nuclei, not in ventral. Dorsal has translocated to the nucleus after cactus is degraded. Controlled by protein known as cactus, outside of the ventral region, cactus prevents. Drosophila proteins often named after mutant phenotype. Loses the ventral cells because there is a lack of the ventral protein (phenotype) Dorsal (the tf) is a morphogen because it determines cell fate based on concentration gradient in nuclei. 3 ways of making a concentration gradient.
