NEURO410 Lecture Notes - Lecture 3: Diffusion Mri, Grey Matter, Mri Sequence
12 Oct 2016
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Lecture 3: neuroimaging in normal aging and ndd: jan 12/16. Limited contrast mechanisms and exposure to ionizing rays. Mechanisms of disease see which areas are affected and rate of degeneration. Treatment strategies (evaluation): (cid:449)h(cid:455) so(cid:373)e (cid:373)a(cid:455) (cid:374)ot (cid:396)espo(cid:374)d to a (cid:862)sta(cid:374)da(cid:396)d(cid:863) t(cid:396)eat(cid:373)e(cid:374)t. Assessment of human anatomy, physiology, and function in vivo non-invasively. Computed tomography (cat scan): attenuation of x-rays by tissue: white = hemorrhage area. See where radioactivity congregates during cognitive process (v5 = visual cortex) Multi contrast mechs for imaging (diffusion, perfusion, flow, magnetization transfer, relaxation times (t1, t2), blood oxygenation etc. ): many things can be measured in the brain; depending on the manipulations, will get different info. Healthy aging, ad, als, pd, hd, hiv, prion, ms. Outline: brief overview of mri, types of info available, exp of findings in various neurological disorders, mri. N: nuclear: looking at nuclei of atoms w/n molecules. M: magnetic: sample placed in strong magnetic field.
