BIOL107 Lecture Notes - Lecture 18: Ribozyme, Start Codon, Peptidyl Transferase

• School: University of Alberta
• Department: Biology (Biological Sciences)
• Course: BIOL107
• Professor: Frank Nargang

Document Summary

Synthesis of proteins from mrna via cytoplasmic ribosomes. Translation requires: ribosomes and mrna, a full set of trnas, amino acids, and charging enzymes (aminoacyl trna synthetases) trnas are small rna molecules that form complex intermolecular base pairs in a stem and loop structure. Bottom loop is anticodon loop and the botton three codons are called the anti codon (in the 5" to 3" direction) Charging enzymes attach specific trna molecules to specific amino acids at its 3" end. Gtp is converted to gdp and phosphate to provide energy for: the assembly of the small and large ribosomal subunit, translocation, and the dissociation of the complex into its original components. The small and large ribosomal subunits are distinct. The small ribosomal unit bonds an mrna and other initiation factors. In prokaryotes, the small ribosomal subunit recognizes the 5" utr (untranslated region) as a. Shine delgarno sequence on the mrna and hence positions mrna correctly for translation.