BIOL107 Lecture Notes - Lecture 15: Adenine, Guanine, Phosphodiester Bond

• School: University of Alberta
• Department: Biology (Biological Sciences)
• Course: BIOL107
• Professor: Frank Nargang

Document Summary

Avery, macleod and mccarthy proved that dna was the genetic material. R-strain (non-virulent) bacteria could be transformed to s-strained bacteria only by dna transfer, not rna or protein transfer. Isolate s strain dna, incubate s strain dna with r cells, dna is taken up by r cells (transformation), r cells become disease causing s cells. The ability to cause disease was cause by s strain dna. Double stranded dna is the genetic material in all organisms. Single stranded dna is the genetic material in some viruses. Dna exists as a dna and protein complex called chromatin. An abundant class of proteins associated with dna is called histones (h1, h2a, h2b, h3, h4) Dna wraps around 8 histone molecules (2 of h2a, h2b, h3 and h4) to form a nucleosome. Entire length of dna in a eukaryotic chromosome is organized into nucleosomes ( beads on a string")