PSYC 280 Lecture 3: Chapter 3 -Neurophysiology

• School: Simon Fraser University
• Department: Psychology
• Course: PSYC 280
• Professor: Neil Watson

Document Summary

C h a p t e r 3. Ion flow creates a local epsp/ipsp in the postsynaptic neuron: s(cid:455)(cid:374)apti(cid:272) tra(cid:374)s(cid:373)itter is either . Inactivated (degraded) by enzymes: removed from the synaptic cleft by transporters so the transmission is brief and accurately reflects the activity of the presynaptic cell, synaptic transmitter may also activate presynaptic autoreceptors, regulating future transmitter release. Exocytosis: process by which a synaptic vesicle fuses with the presynaptic terminal membrane to release neurotransmitter into the synaptic cleft. V-snares: specialized protein anchored to vesicles to aide their fusing to the presynaptic membrane to release neurotransmitter. T-snare: specialized protein anchored to the presynaptic target membrane to bind v-snares to dock vesicles, making them ready for release. Synaptotagmin: specialized protein that responds to calcium ions to trigger vesicular exocytosis. Botulinum toxin: a toxin that cleaves snares, disabling neurotransmitter release. Tetanus toxin: a toxin that cleaves snares, disabling neurotransmitter release.