HSCI 324 Lecture Notes - Lecture 1: Base Pair, Eugenics, Zygosity

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G = p = [260+ (2x64)] / (2x330) = 388/660 = 0. 5878. E = q = [260 + (2x6))] / (2x330) = 272/660 = 0. 41212. Estimate g/g = p^2 = (0. 5878)^2 = 0. 345508, 330(0. 345508) = 114. 017. Estimate g/e = 2pq = 2(0. 5878)(0. 41212) = 0. 48448, 330(0. 484480) = 159. 87. Estimate e/e = q^2 = (0. 41212)^2 = 0. 169843, 330(0. 169843) = 56. 04. G = p = [6 + (2x260) / (2x330) = 526/660 = 0. 796969. E = q = [6 + (2x64) / (2x330) = 134/660 = 0. 203030. Estimate g/g = p^2 = (0. 7969)^2 = 0. 63504, 330(0. 63504) = 209. 56. Estimate g/e = 2pq = 2(0. 796969)(0. 203030) = 0. 32356, 330(0. 32356) = 106. 778. Estimate e/e = q^2 = (0. 2030)^2 = 0. 04122, 330(0. 04122) = 13. 603. The two assignments of genotype classes above do not follow hardy-weinberg proportions because they are not close to the expected ratios. G = p = [64 + (2x6)] / (2x330) = 76 / 660 = 0. 1151.

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