BPK 375 Lecture Notes - Lecture 9: Intramembranous Ossification, Endochondral Ossification, Ossification Center
2 Nov 2016
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Bpk 375 week 9 notes bone growth and development. Clavicle, sometimes preceded by the mandible, other bones ossify in a predictable manner. Ossified parts of the skeleton, cartilage present (i. e. ilium) All bone develops from connective tissue called mesenchyme, which is derived from somites in the embryo. Paraxial mesoderm of somites gives rise to skeletal structures, during refinement the portion that develops into bone become sclerotomes: 2 major ossifications: intramembranous: direct ossification of mesenchyme endochondral: ossification via an intermediate cartilaginous model. Lots of gaps present at the ends of long bones. Osteocyte: mature bone cell that turns over bone mineral and assists in repairs. Osteoblast: immature bone cell that secretes organic components of matrix. Osteoprogenitor cell: stem cells whose divisions produce osteoblasts. Osteoclast: multinucleated cell that secretes acids and enzymes to dissolve bone matrix: bone is good at remodeling and developing due to the certain demands put upon the body.
