BISC 101 Lecture Notes - Lecture 21: Resting Potential, Cell Membrane, Membrane Potential

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A voltage difference and concentration gradients exist across the plasma membrane. Nerve cells have a resting membrane potential of -60 to. 80mv selectively permeable membrane k+ >>> na+ at rest concentration gradients are maintained by na+-k+ pumps. Outward diffusion of k+ via lots of open resting (cid:894)(cid:862)leak(cid:863)(cid:895) k (cid:272)ha(cid:374)(cid:374)els little inward diffusion of na+ due to few open resting na channels inside becomes negative due to loss of k+ (until equilibrium reached) Na/k pump maintains concentration gradients for na and k transporting 3 na+ out for every. Graded potentials = small change in membrane potential where magnitude varies with size of stimulus. Action potential = (cid:862)all or (cid:374)o(cid:374)e(cid:863); (cid:272)o(cid:374)sta(cid:374)t (cid:373)ag(cid:374)itude a(cid:374)d (cid:272)a(cid:374) rege(cid:374)erate alo(cid:374)g a(cid:454)o(cid:374) Depolarization causes action potential = electrical signal. Voltage gated ion channels open and close by changing shape (conformation) in relation to changes in m. p. or voltage difference. If voltage-gated na channels open increase na permeability na flows in = depolarization.

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