Practical Nursing PNH301 Lecture Notes - Lecture 8: Tiotropium Bromide, Weight Loss, Hepatosplenomegaly
26 Feb 2018
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Chronic inflammatory disorder of the airways characterized by recurrent episodes of wheezing, breathlessness, chest tightness, and coughing. Inflammation causes increased responsiveness of the airways to multiple stimuli. The widespread airflow obstruction that occurs during the acute episodes usually reverses either spontaneously or with treatment. Inflammatory cells (basophils & eposinophils) are activated which: The degree of hyperactivity depends on the extent of inflammation. Limited exp airflow traps air distal to the spastic a/w. Trapped air mixes with inspired air in alveoli reducing its o2 tension & gas exchange across the alveolar capillary membrane. Blood flow is reduced to distended alveoli further affecting gas exchange. Hypoxemia & increased lung volume (d/t trapping) stimulate resp rate. Excess fluid in the lungs resulting from acute inflammation. Triggered by infectious organisms and inhalation of irritating agents. Significant cause of hospital admission and death from infectious disease in. Leading cause of death of children worldwide (who, Usually abrupt onset of fever and chills.
