PAT 20A/B Lecture Notes - Lecture 5: Grapefruit Juice, Lipoprotein, Coronary Circulation
9 May 2016
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Week 5: pathos: artheocoloresis: explain how pathophysiological processes including the inflammatory response, endothelial cell dysfunction, vascular inflammation and hyperlipidemia result in the physiological changes to the vascular system resulting in atherosclerosis. Identify how the inflammatory process including the role of monocytes, ldl and t lymphocytes impacts on the formation of atherosclerosis and thrombosis: discuss the pathophysiological changes associated with the 4 stages atherosclerosis development, i. Intact normal endothelium is more than a simple barrier between the vessels wall and the lumen of the vessel. Non-reactive to platelets and leukocytes, as well as coagulation, fibrinolytic and complement factors. However, can get damages because of tobacco use, hyperlipidemia, hypertension, diabetes- which causes a local inflammatory response. C-reactive protein (crp)- produced by liver, non-specific marker of a inflammation. Crp roses with systematic inflammation and is increased in many pt. with cad. Chronic elevation of crp are associates with unstable plaque and the oxidation of low-density lipoprotein *ldl*.
