PAT 20A/B Lecture Notes - Lecture 4: Menorrhagia, Constipation, Methemoglobinemia
20 Apr 2016
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They the enzymes cycoocygenase (pg pathway) and leukotriene (lt pathway) reduce fever by inhibiting pge2. Contraindications: known drug allergy and conditions that place the patient at risk for bleeding. Includes rhinitis (risk of epistaxis [nosebleed]), vitamin k deficiency, and peptic ulcer disease. Adverse effects: gi distress, ranging from mild symptoms such as heartburn to most severe gastrointestinal complication, gastrointestinal bleeding, cox-1 inhibitors e. g. ibuprofen, ketorolac. Isoform of the enzyme that promotes the synthesis of homeostatic pgs, which has primarily beneficial effects on various body functions. Half life po: less than 30 min. Lowest possible dose be given for the shortest duration possible. Only nsaid that can be given orally or by injection. Duration 4-6 hr: cyclooxygensase-2 (cox-2) inhibitors. The cox-2 isoform promotes the synthesis of pgs that are involved in inflammatory processes. These nsaids work by specifically inhibiting the cox-2 isoform of cyclooxygenase and have limited or no cox-1 effects (others worked non-specifically)
