PAT 20A/B Lecture Notes - Lecture 2: Cell Adhesion Molecule, Endothelium, Inflammation

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: Beth Swart

Document Summary

Inflammatory conditions are commonly adding the suffix "-it is" to the affected organ or system. >destruction of pathogens: after release from bone marrow---> life span of 4-10 hours, must be constantly replaced. Secreted by plasma cells through receptors on their cell surface. Release of preformed contents of their granules. Synthesis of lipid mediators derived from cell membrane precursors. Stimulation of cytokine and chemokine synthesis by other cells such as monocytes and macrophages: lymphocytes and plasma cells, lymphocytes: Thin rim of cytoplasm surrounded by deeply staining nucleus. Involved in immune-mediated inflammation caused by infectious agents as well as non-immune mediated inflammation associated with cell-injury and death. Both t and b lymphocytes migrate into inflammatory sites using some of the same adhesion molecules and chemokines that recruit neutrophils and other leukocytes. Macrophages display antigens to t cells, express costimulators (membrane molecules), produce cytokines that activate macrophages: increases antigen presentation and further cytokine production, plasma cells: develop from activated b lymphocytes.