BMS 870 Lecture Notes - Lecture 6: Muscarinic Acetylcholine Receptor, Reactome, Neurotransmitter
28 Oct 2017
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Document Summary
Pick article of interest (original research) published recently. Structure of gpcrs: single polypeptide w/ 7 membrane-spanning -helices connected to g- protein complex consisting of 3 subunits. Gdp -> gtp on a-subunit = a-subunit active = moves within membrane and contacts different proteins. Opsin type (vision), taste, peptide nt system, for adrenergic system. Rhodopsin - largest, 4 main groups w/ 13 sub-branches. Systematic annotation of the 3 main gpcr families in reactome. Popular in medicine: adrenergic receptors imp to how heart, respiratory membrane works. Heart disease - use drugs that are antagonist of the nt. Muscarinic receptors imp in many parts of body. Can keep activating a-subunit as long as nt bound to gpcr. Eventually clear out nt as to not desensitize receptor. a-subunit"s gdp exchanged for gtp, activating a-subunit a-subunit moves and activates several enzymes like adenylyl cylase, which converts atp to. Ga inactivates by slowly converting gtp to gdp. Ga and gby recombine and start sycle again.
