BMS 607 Lecture Notes - Lecture 8: Insertional Mutagenesis, Insitu, Wild Type

• School: Ryerson University
• Department: Biomedical Sciences
• Course: BMS 607
• Professor: Sarah Sabatinos

Document Summary

Genome - the total digital i(cid:374)fo(cid:396)(cid:373)atio(cid:374) (cid:272)o(cid:374)tai(cid:374)ed (cid:449)ithi(cid:374) the dna se(cid:395)ue(cid:374)(cid:272)es of a(cid:374) o(cid:396)ga(cid:374)is(cid:373)"s chromosomes. The pace of moore"s law (the observation that computing power doubles every 18 months) is shown in white. As you can see, advances in sequencing technology (resulting in lowered cost) easily outpace moore"s law. Human genome project is a composite, so is called a reference: was derived from a small number of anonymous donors, no idea about variation within individuals. 1988: u. s. national academy of sciences considers merit of the human genome project (hgp). 1990: hgp begins a 15-year timeline, billion budget. 1998: celera vows to sequence hg in 3 years, independently. Feb 2001: rough draft completed by hgp. (cid:1006)00(cid:1007): 97% (cid:272)o(cid:448)e(cid:396)age, esse(cid:374)tially (cid:862)do(cid:374)e(cid:863) (cid:894)ahead of s(cid:272)hedule! (cid:895) April 2013: 9327 species genomes sequenced, includes 112 vertebrates. Haploid assembly each autosome pair is counted once (22 pairs), plus x and y chromosomes -