BLG 508 Lecture Notes - Lecture 8: Mutation Rate, Point Mutation, Base Pair

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25 Jul 2016
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The fate of a new allele will: be fixed in a population, increase in frequency and get fixed, lost, or random; Depends on weather its beneficial, deleterious or neutral. Used in laboratory organisms to look at the effects of mutations. They took c. elegans which are hermaphrodites, then they reproduced genetically identical lines from a single individual (74 lines genetically identical like clones) Compared fitness of mutation accumulation lines to controls: the controls lines had natural selection occurring in lab culture, there was competition for resources and the largest group of parents was chosen randomly from survivors. 74 control (selected) lines: they started genetically identical from a single parent. Accumulation of mutations = decrease in fitness of 0. 5% per generation. Mutation accumulation line steady decrease in percentage surviving to maturity (all mutation in the population: individuals die at early stage without reproducing.

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