PHAR 340 Lecture Notes - Lecture 5: Facilitated Diffusion, Active Transport, Adme
20 Sep 2019
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Keep [drug] in the range b/w mec for desired response and adverse response. Need to give lag period for drug to absorb and distribute. Be taken (compliance forget, too annoying) #1 problem. Mouth to anus is a tube, need to be absorbed into body. Ionization of drug (ionized less likely to cross membrane) Diffuses into cell without energy down cg using carrier. Specificity of receptors to bring specific molecules through. Move into cell using energy against cg to concentrate on one side. Abc (atp binding cassette) use atp to move drugs out of cell (7) Slc (solute carrier) use atp to move drugs into cell (48) Move into cell using energy through pinching off the membrane to engulf drug and ecf. Not common for drugs unless it"s a protein. At physiological ph, weak acids and bases are ionized ph < pka: bases are (+), acids are (+-) ph > pka: acids are (-), bases are (+-)
