PHAR 340 Lecture Notes - Lecture 10: Plasma Protein Binding, Glucuronide, Phenytoin
23 Dec 2018
School
Department
Course
Professor
Document Summary
Forced alkaline diuresis: makes indiv pee more, na bicarbonate added to make urine more alkaline so drug cant move back into blood (keeps it ionized), k also added. Excretion of high mw, polar comp, many glucuronide conjugates. Alt by enterohepatic circ where conjugated drugs is hydrolyzed back to parent by bacteria in li (have b-glucuronidase) and then reabsorb into blood. Oc- dose is so low it depends on enterohepatic circ to be effective, not effective if on antibiotics bc it wipes out gi flora interfering w enterohepatic circ. Excretion depends on ph and drug pka, resp for skin rxs maybe. Lactation affects baby mainly, factors include lipid sol, ph of blood/milk, extent of active transport + plasma protein binding. Volatile sub via simple diffusion, sol of gas and cardiac output incr excretion sig for forensic reasons (alcohol testing) + anesthetics. Ex. baby overdosed because mother was taking codeine which metabolized into morphine and killed the baby.
