PHAR 100 Lecture Notes - Urinary Tract Infection, Beta-Lactamase, Phenoxymethylpenicillin

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Hisham Elbatarny

Document Summary

Paul ehrlich father of chemotherapy, used organoarsenicals syphilis: domagk sulfonamides, waksman streptomycin. G : cell wall is different: g- cell wall doesn"t take up gram stain, while g+ lacks a component of the cell wall and ca. Classification organism: narrow spectrum: e. g. penicillin acts on g+ only, broad spectrum: acts on both g+ and g , bactericidal: kill the organism, bacteriostatic: prevent multiplication of organism and defense mechanism of the host remove. Gram positive does not have this layer. D-al d-al acts on peptidogyglan: inhibits the synthesis of this layer. Resistance: some organisms can produce enzyme beta- lactamase that breaks down penicilin. Fluoroquinolones: ciprofloxacin highly abused b/c it is broad spectrum, lots of resistance, broad spectrum g+ and g , inhibits dna gyrase (ie topoisomerase ii) and protein synthesis. Inhibits protein synthesis: used where individual allergic to penicillin, also used for some g infections.