PHAR 100 Lecture Notes - Insomnia, Morphine, Barbiturate

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Hisham Elbatarny

Document Summary

Introduction: drug dependence, tolerance, dependence, addiction, drug abuse, medical perspective, social perspective, abuse potential, intrinsic dependence liability, availability, inherent harmfulness. Have to take data w/ a grain of salt: some people may lie. Harmful a pattern of psychoactive use that is causing damage to health continue to use the drug even though the user recognizes the potential damage damage can be physical (hepatitis) or mental (depression) Drug dependence three important aspects of drug dependence: tolerance, dependence (physical dependence, addiction (psychological) Tolerance repeated administration of a given dose of drug has progressively less effect in other words: the dose of a drug must be increased to obtain the same magnitude of pharmacological effect that was first achieved. B interacts with a different receptor: ex: benzodiazepine and alcohol: both bind to gaba receptors, but different sites. Metabolic tolerance: drug metabolism and elimination increased: up-regulation of enzymes: break down more drug, less drug at site of action.