PHAR 100 Lecture Notes - Lecture 1: Pre-Clinical Development, Reserpine, Angina Pectoris
17 Oct 2017
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Lesson 1. 1: history of drug use and development. In some societies, medicine men were both physicians and priests. Leading to them using the toxic substances around them to treat and heal others. In mexico, peyote cactus was used to reach a mystical state, hallucinate, produce well-being feelings and distort perception, as it contains mescaline, a potent substance. Medicine derived from study of poisons/toxic substances, which is backed up by 16th century swiss physician paracelsus. Burning in limbs: middle ages a s holy fire/st. Constriction of blood vessels: fingers, toes and limbs starved, leading to death/falloff. Mental frenzy, hallucinations, and convulsions: some contained lsd. Abortion: cause contractions of uterus, which can be violent. Early chinese: earliest recorded 2700 bc by emperor shen nung who tasted drugs in order to classify them, ex: ma huang classified as medium drug, widely used for coughs, influenza, and fevers.
