PATH 310 Lecture 12: Acute Leukemia

• School: Queen's University
• Department: Pathology and Molecular Medicine
• Course: PATH 310
• Professor: Christine Hough

Document Summary

Hematopoietic stem cells: hematopoietic stem cells (hsc) are found in the bone marrow, cord blood, and in smaller numbers in the peripheral blood. Long-lived cells that give rise to all blood cells: comprise approx. Hematopoiesis: hematopoiesis is the process of creating new blood cells in the body. All blood cells start off as hematopoietic stem cells, and then specialize (differentiate) into myeloid cells (erythrocytes, megakaryocytes, monocytes, neutrophils, basophils, or eosinophils) or lymphoid cells (t-lymphocytes and b-lymphocytes). In adults, primarily occurs in the bone marrow: hsc: hematopoietic stem cell. Ly(cid:373)phoid a(cid:272)ute l(cid:455)(cid:373)pho(cid:271)lasti(cid:272) leuke(cid:373)ia (cid:894)all(cid:895) chro(cid:374)i(cid:272) l(cid:455)(cid:373)pho(cid:272)(cid:455)ti(cid:272) leuke(cid:373)ia (cid:894)cll(cid:895) Leukostasis, tissue i(cid:374)filtratio(cid:374), orga(cid:374) failure, e(cid:374)larged l(cid:455)(cid:373)ph (cid:374)odes or splee(cid:374) Idiopathic (acquired somatic mutations): (cid:272)a(cid:374)(cid:859)t pi(cid:374)poi(cid:374)t (cid:449)h(cid:455) the(cid:455) got leuke(cid:373)ia. Increased risk of luekemia: genotoxic exposures, radiation, chemotherapy (i. e. for another cancer, benzene, smoking, history of other blood cancer (i. e. cml, mds, genetic predisposition syndrome (i. e. fanconi anemia, strong family history.