PATH 310 Lecture Notes - Lecture 3: Mutation, Covalent Bond, Hepatocyte
19 Mar 2017
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Document Summary
After exposure of tissue factor and initiation of extrinsic pathway, factor 10 is activated to factor 10a. Positive feedback loop initiated by small amount of thrombin which feeds back and amplifies the pathway. Factor 8 and 9 occur within this intrinsic feedback loop. The feedback loop is important in developing a normal blood clot. It is switched off by the presence of tissue factor pahway inhibitor. Once the system has been started, it is regulated by this negative inhibitor. The extrinsic pathway has been switched off, and the intrinsic pathway is not working because they are missing either factor 8 or 9. Factor 8 and 9 are essential to produce a normal blood clot. Factor 8 and 9 work in this model. Blood coagulation does not occur in the fluid phase, it is limited to surfaces on cells like blood platelets, endothelial cell injury, blood vessel injury. The enzyme is the active form of factor 9.
