PATH 310 Lecture Notes - Lecture 3: Thrombomodulin, Fibrinolysis, Plasmin
6 Mar 2017
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Document Summary
Thrombin acts as enzyme for fibrinogen to fibrin. When in complex with thrombomodulin it inhibits this. Binds anti-thrombin to accelerate inhibition of thrombin. Binds thrombin to activate protein c a anticoagulant. Inhibits extrinsic pathway: plasminogen converted to plasmin. Inhibitor of enzyme: plasminogen activator inhibitor: plasmin inhibited by. Product inhibits thrombin: positive feedback of inhibition, breakdowns stop making more. Thrombosis: formation of thrombus toward direction of the heart. Risk events of thrombosis: arterial thrombosis. Immobility or paralysis: before entrance of valve, when valve closes there is turbulent flow causing build up, made up of red blood cells, etiology unknown. Deep venous thrombosis leads to pulmonary embolism 1/3 of time: leg and pelvis, both end in thrombus blocking pulmonary artery. Vwf levels correlate with blood type: a or b = high, type o = low. Antigens on a, b, ab clear vwf because it is glycosylated.
