MICR 360 Lecture Notes - Lecture 12: Cytokine, Immunoglobulin M, Cfu-Gemm

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

So you have hematopoietic stem cell this becomes a multipotent progenitor and then a common myeloid progenitor or a common lymphocyte progenitor. The common myeloid progenitor can further develop to mature blood cells! We are going to focus on the common lymphocyte progenitor. Okay so three possibilities for the common lymphocyte progenitor. You can have pre nk cells pre b cell or a thymocyte. The pre nk becomes a nk cell ; the pre b cell becomes a b cell; the thymocyte becomes a t cell. Vdj and vj gene rearrangement occur in the bone marrow. This is followed by the selection of non-self reactive b cells. Omg only 1/10 or like 10% of b cells that are actually made leave the bone marrow! Immature igm -bcell leaves the bone marrow ! this immature igm b then circulates in the blood and is carried to the secondary lymphoid organs like the spleen where it gains igd expression.