MICR 221 Lecture Notes - Lecture 26: Vise, Icosahedral Symmetry, Rhabdoviridae
24 Apr 2018
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Document Summary
Virus structure- det via bacteriophage + cell culture sys. Proteolytic and nucleolytic enzymes, extremes of ph/temp, natural radiation, shearing via mechanical forces (large dna viruses) Info necessary to specify structural proteins must not exhaust coding capacity of genome. Particle must be stable enough to protect the nucleic acid in extracellular enviro but still attach to host cell. Adenovirus: virus w knob rhabdovirus: bullet shaped, like rabies. Nucleocapsid structure composed of capsid containing nucleic acid or core. Viral memb consisting of lipid bilayer containing spike proteins. Viral glycoproteins that project from envelope ex. corona virus. Protein shell that encloses + protects viral nucleic acid, hiv has weird capsid structure package genomes via helical capsids or capsids w icosahedral symmetry. Helical: plant viruses, bacteriophages, animal viruses w envelope and rna never dna, vary from flexible (paramyxovirus, ex measles) to rigid (rhabdovirus ex. rabies) Open structures w ends of rods unsealed ex.
