BIOL 206 Lecture Notes - Lecture 9: Familial Adenomatous Polyposis, Genetic Disorder, World Health Organization
2 Feb 2017
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Lecture 9 genetic disease: diversity of genetic diseases, mutation-selection balance, effect of medicine on disease. *** when we say disease we mean alternative phenotypes or conditions. Single-gene diseases: common, diverse & cause much death. World health organization (who) estimates ~10,000 monogenic human diseases that have been recorded so farf. In canada 40% of all pediatric care is just to manage these monogenic diseases. Categories: caused by dominant mutation, recessive mutation and x-linked mutation. Answer: natural selection is reducing alleles that reduce fitness but mutations are constantly inputting the alleles back into the population. 2] using directional selection model to predict human disease. Let"s go (cid:271)a(cid:272)k to the directional model and thinking about selecting against the recessive allele. Change due to selection: selection is always reducing q (the freq of the recessive allel, selection is working to get rid of these mutation. Bc only the normal allele can mutate to become mutation.
