BIOL 205 Lecture Notes - Robertsonian Translocation, Nondisjunction, Cri Du Chat
8 Nov 2013
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Document Summary
Most disjuction problems happen in the meiosis i, but those in meiosis ii more commonly known. Things to know about changes in chromosome structure. Duplications or deletions affect gene balance: the larger the duplication or deletion the larger the problem. Chromosome abnormalities error in the cell division groups: Gain (duplication: change in the amount of chromosome (piece or whole) e. g. trisomy 21 (down syndrome, change in the structure of chromosome. Most of the time come from non-allelic, non-homologous recombination. Human genome ~ 45% repetitive dna: gives lots of oppertunities to find different sequences that are similar. Down syndrome (?) they code for a cell adhesion molecule, protein kinase. Unaffected children may be normal or translocation carriers. Bcr function? targeted therapy: relocation of an oncogene next to a novel regulatory element: burkitt lymphoma, formation of a hybrid oncogene: chronic myologenous leukemia. Regulatory region in chr14 now controlling myc gene. Fusions with an oncogene can lead to abberent expression.
