BIOL 102 Lecture 8: Transporters; Enzymes, Metabolism, and Free Energy
Document Summary
Lecture 8 - protein transporters; enzymes and metabolism. Places into low af nity state; releasing cargo. Different types of transporters; uniporter (moving one cargo at a time), symporters (more than one, can by co-transporters or aniporter) Binding produces conformational change activating next transporter. Moving things against energy potential gradient; needs energy. Pumps; couples conformational changes to an energy source; ex atp-driven pumps. Er can tolerates high levels of calcium excess calcium goes there. Sometimes moving down gradient requires energy because conformational change that transporter goes through is just thermodynamically unfavourable. Cystic fibrosis is example where this occurs. Solutes cannot move through the transporter; causing thick mucus to build up in lungs. Small primary mutation leads to tertiary change = lead to disease. Function of transporter no longer works effectively; thing usually not suppose to move actually go through; big problem! Endomembrane system; co-translational coding (synthesized in er), comes out though vesicles to golgi.
