NSCI 324 Lecture 12: Visual system II - Retina

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Axons come out, go to optic disk, optic nerve, brain. Centre surround organization: centre piece and donut around. On centre: when light spot goes on, it gets exiting, discharges more action potentials, exicted when light hits centre. Off centre: when light comes on it is inhibited, has rebound of activity when light goes off, opposite of on-centre, inhibited when light hits centre. Dark spot in centre at t1, dark spot. How to get on-centre and off-centre receptive fields. Photoreceptor is in depolarized state, but with light spot there is conformational change in dendrites, change in gmp present, hyerpolarizes, reduces neurotransmitter across synapse to bipolar cells. 2 different kinds of bipolar cells: different types of receptors for nt across synapse. Nt xcitatory on bipolar cell, nt is inhibitory on other bipolar cell. Less nt going across, if it is normally excitatory, then less nt going through that so less excitatory off-centre.

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