LIFESCI 2G03 Lecture Notes - Lecture 15: Histone Deacetylase, Covalent Bond, Methyltransferase
19 Mar 2018
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Document Summary
Epigenetics: the covalent modification of dna and dna associated proteins that affect gene exp without altering the primary nucleotide sequence. Epigenetic modifications may be stable and heritable states or dynamic and changing in respon environmental stimuli. Nutrition, behaviour, stress, physical activity, working habits, alcohol consumption. The activator protein recruits tfiid to the core promoter and/or activates its function. Tfiid is just one example of a transription factor. Intiation of transcription by binding of a rna polymerase. Steps: (1) dna sequence (enhancer sequence) has to be specific and recognizable (2) activator protein must be present that"s going to bind to sequence. It increases affinity of rna polymerase at transcription initiation site. Steps: (1) binding of repressor proteins to silencer sequences prevent transcription. By decreasing affinity of rna polymerase at transcription initiation site or by e expression ponse to tion scription will be r by preventing. By decreasing affinity of rna polymerase at transcription initiation site or by activity of rna polymerase.
