KINESIOL 4SS3 Lecture Notes - Lecture 3: Superoxide Dismutase, Hayflick Limit, Twin
19 Sep 2016
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Document Summary
1960s convinced aging was all in genes, no control. 80s more focus on, how cells defend against environment and maybe more failure of defense mechanisms. 2000 more genes geared towards longevity, cell defences broader view. 2000+ - secondary influences, lifestyle, diet, environment plus all past ideas. Assumption that biological clock" is programmed into each cell. Genes exert positive (or negative) effects on longevity by altering biological make- up of the organism. How important are parents in determining age longevity: long lived parents are not a guarantee of longevity, but genetics are important. Twin studies identical twins share more similar life spans that fraternal twins: can"t control environment after leaving homes. Genetic diseases related to premature aging: progeria. Accelerated aging in all systems of body. Abnormality on chromosome 1 (mutation of gene coding for lamin a) Keep nuclear membrane intact so nucleus maintains circular shape. Nuclei become squished and not as effective in every cell in body: werner"s syndrome.
