HTHSCI 2H03 Lecture Notes - Lecture 5: Anterior Pituitary, Corticosteroid, Circulatory System

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 2H03
• Professor: J. Fader

Document Summary

Normal effect: increases blood glucose levels, increases the breakdown of lipids and prote responses, increases vascular smooth muscle sensitivity to ne and angiotensin ii, affects mood and cn. Corticotropin-releasing factor (crf) produced by the hypothalamus as a result of circadian rhy. Adrenocorticotropic hormone (acth) produced by the anterior pituitary. Increased levels of cortisol negatively feedback to the hypothalamus and anterior pituitary to turn of. The hormone responses by acting as transcription factor mineralocorticoids(aldosterone) Normal effect: regulates sodium and potassium re-absorption in the kidney. Cellular mechanism of action: binds to intracellular receptors (is lipid soluble). The hormone responses by acting as transcription factor. Inadequate secretion of acth from the anterior pitu. Addison"s disease: primary adrenal insufficiency resulting from the autoimmune destruction of both adrenal glands. Secondary adrenal insufficiency: caused by chronic, l leading to adrenal atrophy. Hyposecretion of cortisol and aldosterone resulting in hypogl diarrhea, dehydration, decreased plasma sodium levels.