HTHSCI 2H03 Lecture Notes - Lecture 9: Etonogestrel, Jaundice, Cyclic Adenosine Monophosphate
15 Nov 2016
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Document Summary
Water soluble endocrine hormones to cell surface receptors leads to the manufacture of second messengers (e. g. camp or ip3) which alter cell function. Activate g proteins: norepinephrine, epinephrine, oxytoxin. Bind to extracellular receptors that activate protein kinases directly (no 2nd messengers: insulin, growth hormone. Move through bloodstream bound to transport protein. Form complex with receptor and bind to dna inside cell. Ex: estrogen, testosterone, progesterone, thyroid hormone, cortisol, aldosterone. Regulation of female reproductive hormones: gnrh (hypothalamus, luteinizing hormone and fsh produced in the anterior pituitary, sex steroids (progesterone, estrogens and androgens) produced in the gonads. Secondary sexual characteristics (body hair, muscle growth etc much depends on. Hormone changes in females gender: surge in lh & fsh = ovulation, increased estrogen and progesterone = endometrial vascularization + thickening, decreased gnrh, lh & fsh= decreased estrogen and progesterone =menstruation. Estradiol: the major ovarion estrogen, most potent of all 3 estrogens, arises from the action of aromatase on testosterone.
