HTHSCI 1LL3 Lecture Notes - Lecture 10: Point Mutation, Pyruvate Dehydrogenase, Succinic Acid

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 1LL3
• Professor: Dr McCurdy

Document Summary

The tricarboxylic acid cycle and the electron transport chain. Energy metabolism: e- are shuttled to etc. If o2 isn"t there, everything gets backed up bc the e- needs to bind to the o2 to turn into h2o. The tricarboxylic acid cycle: the oxidation of all of the different fuels can generate acetyl coenzyme a (acetyl. Coa oxygen is the ticket for entry into the tca cycle to generate atp much more efficiently. Oxidation and reduction: oxidations and reductions are the reactions that drive energy generation, to remember which is which leo the lion says ger . Oxidation and gain of electrons = reduction: nad+ and fad are reduced in the tca cycle and then regenerated by oxidation in the electron transport chain. Pyruvate dehydrogenase complex: without the ability to convert pyruvate to acetyl coa, this product of glucose metabolism cannot enter the tricarboxylic acid cycle.