HTHSCI 1LL3 Lecture Notes - Lecture 8: Central Dogma Of Molecular Biology, Antimicrobial Resistance, Cytosol
6 Mar 2017
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Central dogma of molecular biology: dna transcription to rna and its" t(cid:396)a(cid:374)slatio(cid:374) i(cid:374)to p(cid:396)otei(cid:374) is k(cid:374)o(cid:449)(cid:374) as the (cid:862)(cid:272)e(cid:374)t(cid:396)al dog(cid:373)a(cid:863) of (cid:373)ole(cid:272)ula(cid:396) (cid:271)iolog(cid:455), (cid:449)hi(cid:272)h is a field (cid:272)losel(cid:455) (cid:396)elated to (cid:271)io(cid:272)he(cid:373)ist(cid:396)(cid:455) It refers to the information flow for biological systems which goes in the direction from. Biomolecules: dna resides in the nucleus, rna is transcribed in the nucleus and translated in the cytosol, proteins are chains of amino acids, translated in the cytosol but involved in all different areas of the cell. Dna bases: adenine and guanine are the purine bases (larger, cytosine and thymine at the pyrimidine bases (smaller) Nomenclature: the sugar bonded to a base is called a nucleoside, once phosphates are added they are called nucleotides, one to three phosphates can be added. Dna bond formation: the bond btw the nucleotides is an ester linkage, but there are 2 of these bonds, both involving the same phosphate group, so it is a phosphodiester bond.
