BIOLOGY 2C03 Lecture Notes - Lecture 3: Sickle-Cell Disease, Allele Frequency, Population Genetics
13 Mar 2018
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Mendelian population = interbreeding group that share same "gene pool" Microevolution = changes in the "gene pool" = changes in frequencies of different alleles and the loss and gain of alleles. O(cid:271)se(cid:396)vatio(cid:374): the s mutation appears with high frequency in several contemporary populations. Hypothesis: the s mutation confers a selective advantage. Serious complications involving kidneys and brain can develop; may lead to delirium and coma. Malaria = chronic; individuals are susceptible to other infections which may lead to death. Plasmodium embryos live in mosquito but begin larval development in mammalian host. Larvae mature in liver of host and then red blood cells. Sickled red blood cells = fragile, average rbc lifespan in heterozygotes is shorter due to the abnormal hemoglobin. Shorter lifespan interrupts life cycle of the larvae preventing proliferation of malaria in host. Thus, s s a(cid:374)d s a ge(cid:374)otypes (cid:373)o(cid:396)e (cid:396)esista(cid:374)t to (cid:373)ala(cid:396)ia tha(cid:374) a a.
