BIOLOGY 1A03 Lecture Notes - Lecture 15: Chromatin Remodeling, Epigenomics, Epigenome

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Alastair Tracey Rosa Da Silva

Document Summary

Signals detected by cells (environment cues: = cell communication, signal received, receptors on target bind to signal, signal transduction cascade can lead to short/long term responses in cell, short = metabolism, movement. Signals can act on epigenome to alter gene expression. Mother: folic acid supplement = high methyl source = minimize open spinal cord of baby. Cancer: mis-regulated epigenetics, no methylation = divide a lot/increase growth, over methylate = decrease cell death. Fluorescent: green: expressed in normal cells, red: expressed in breast carcinoma cells, yellow: expressed equally in both. Identical genes & chromosomes but end up w/ different characteristics. Almost identical epigenetic microarray analysis in 3-year old twins, different in 50-year-old twins: different environments/habits/lifestyle (i. e. smoking) Dr. parminder raina: evolution of epigenetic markers, relate epigenetic markers to health, social, environment", microarray measurement of epigenomes. Human epigenome project: correlate epigenome and disease.