SOCI 588 Lecture Notes - Lecture 7: Glucocorticoid Receptor, Epigenome, Brain-Derived Neurotrophic Factor
18 Feb 2016
School
Department
Course
Professor
Document Summary
Claim that a critical issue is that of relating the epigenetic modiications at speciic dna regions to function. They highlight that in the living animal, under normal conditions, there is more ngfi-a associated with the exon 17 promoter in hippocampal neurons of adult animals reared by high- compared with low-lg mothers. There is also evidence that directly links the maternal efect on the epigenetic state of the exon 17 promoter to the changes in glucocorticoid receptor expression and. These results are critical as they suggest that fully mature neurons in an adult animal express the necessary enzymatic machinery to demethylate or remethylate dna. Evidence that learning and long-term memory commonly require changes in gene expression and protein synthesis. Evidence was found for the importance of epigenetic modiications of histones in the amygdala during fear conditioning, as well as evidence for the importance of dynamic changes in dna methylation at speciic sites during learning and memory.
