PHGY 311 Lecture 16: PHGY311 Sjostrom 6 Aplysia
6 Nov 2016
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Document Summary
Aplysia, hippocampus, ltp: basis for memory formation is in changes in: Circuit/synapses btwn sensory/motor neurons: behavioural learning in aplysia requires plasticity. Harmful stim = sensitization = nt release = stf: relies on 2 pathways, blok k+ channels to prolong spike, mobilize reserve pool vesicles to incr rrp/recovery rate. Homo = input specific: aplysia shows homosynaptic depression. Hetero = not input specific: aplysia sows heterosynaptic facilitation/short term sensitization as seen below: If you combine habituation and sensitization stimuli need to pair them temporally to induce associative learning/long term. If not paired temporally, it will induce habituation/std like before. Expression = how ltp/ltd manifests: ex. Ltp induction: glu must bind nmdar, post synaptic neuron must depolarise to remove mg++ from. Nmdar: open nmdar = ca++, na+ influx, ca++ binds calmodulin, which binds: No synthetase: retrograde signal to presyn, prelease: n = #synapses (pre+post/neither expression, p = #vesicles of nt released (presynaptic expression, q = #ampars, quantal amplitude change (postsynaptic expression)
