PHGY 209 Lecture Notes - Lecture 6: Clonal Anergy, Clonal Selection, Ctla-4
16 Sep 2016
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Linus pauling: floppy protein models wind around antigens (direct template theory) o proteins are instructed on how to fold. Paul ehrlich: if you give a lot of toxins, the cell will die, if you give a little bit, it will survive and neutralize (side chain theory for antibody production) o antibody molecules know how to be synthesized. B-cell goes through various stages during its evolution. Pro-b cell, still in the fetal liver or making its way to the bone marrow, has no marker no sig. Pre-b cell begins to have a heavy chain: mature b-cell which has been specified can only react with one peptide. Plasma cell makes antibodies and secretes them but it loses its sig it is no longer required. 3 pieces for the immunoglobulin chain heavy chain: 50 variable pieces alleles of a gene, diversity piece (25 alleles) o joining piece (6 alleles, constant region required to make the class.
