PHGY 209 Lecture Notes - Lecture 5: Cytosol, Caveolae, Endothelium
15 Apr 2018
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Document Summary
Changes in the binding site affinity for a transported solute are produced by phosphorylation and dephosphorylation of the carrier. The change in conformation allows the for the outside to be exposed to the milieu and k binds and the phosphate is released. Carrier involved is actually the enzyme atpase which can split atp on the cytoplasmic side of the membrane, and thus release the necessary energy. Carrier molecule binds na+ on the cytoplasmic surface of the membrane. This results in the activation of atpase and the consequent release of energy. Through the change in configuration, the carrier delivers na+ to the outer surface, as it permits the exposure of the binding site for k+ on the outer surface as well. , h-atpase- removes h ions out of cells. , h/katpase- involved with acidification in stomach: secondary active transport- doesn"t get energy directly from atp- there is a reservoir of energy that is stored in the concentration of energy.
